Academic profile · 2026
Ziyue (Siyana) Zhang
My research interests lie at the intersection of synthetic chemistry and intelligent technologies. Trained as a synthetic organic chemist, I combine experience in reaction development, optimization and natural product modification with self-initiated exploration of data-assisted synthesis planning. I enjoy integrating experimental chemistry with computational thinking to develop more intelligent and efficient approaches to chemistry.
Education
2024–2025 comprehensive assessment, including competition distinctions.
Organic synthesis, agrochemical discovery, and late-stage modification of bioactive natural products.
Outstanding Bachelor Graduate.
Pharmaceutical engineering, analytical chemistry, and early research training in a graduate group.
Looking ahead
I hope to contribute to a future where chemistry is not only driven by experimental expertise, but also empowered by intelligent algorithms, automation, and data. My long-term goal is to develop technologies that enable chemists to discover molecules more efficiently while preserving the creativity and intuition at the heart of scientific research.
01 · Publications
Organic Letters · 2025
Contribution Substrate synthesis, reaction experiments, characterization, and Supporting Information.
Skills applied & developed Visible-light photochemistry · substrate design and synthesis · reaction-scope evaluation · spectral interpretation.
Read paper ↗
Organic Process Research & Development · 2026
Contribution Contributed to experimental synthetic research.
Skills applied & developed Retrosynthetic route design · multistep synthesis · reaction optimization · scale-conscious execution.
Read paper ↗02 · Research
Master’s thesis · Natural-product modification
Designing pleuromutilin derivatives through C14 side-chain modification and scaffold editing for agricultural antibacterial applications, alongside an exploratory study of constraint-aware synthesis planning.
Methodology development · Project lead
Under peer review · The Journal of Organic Chemistry
Developed a sequential solvent-free Michaelis–Arbuzov rearrangement platform, prepared fluorinated variants, and evaluated their performance under standardized Mitsunobu conditions.
Agrochemical discovery · SDHI design
Under peer review · Journal of Agricultural and Food Chemistry
Contributed to the design, synthesis, and characterization of pyrazole-4-carboxamide and aromatic carboxamide derivatives, while gaining initial experience with molecular docking and related computational methods.
Industrial collaboration · Route development
Contributed to shortening the longest linear sequence from 12 steps to 7, developed one-pot operations, explored photocatalytic and microchannel-flow conditions, and achieved kilogram-scale production. Related results are under patent application.
Undergraduate thesis · Analytical chemistry
Developed chiral HPLC analysis and preparative HPLC separation to isolate four stereoisomers, with structural confirmation by ¹H/¹³C NMR.
03 · Research background
Chiral HPLC, GC–MS, method development, and structural characterization.
Retrosynthesis, reaction optimization, telescoped synthesis, and scale-conscious execution.
Reaction development, agrochemical discovery, and late-stage modification.
Ongoing preparation for experimentally grounded, data-enabled discovery and laboratory automation.
04 · Beyond research
Team leadership · Quantitative modelling
2024
Led collaborative problem framing, task coordination, and model development in a time-constrained national competition. The experience strengthened my interest in using quantitative models to interpret complex problems and informs my exploration of data-driven chemistry.
Laboratory service & mentoring
Assist with selected administrative, financial, and laboratory-management tasks, and help junior students become familiar with experimental practice and group routines.
Student communication
Invited in two consecutive years to speak to incoming students and share practical reflections on study, research, and the transition into university life.
Academic community
Participate in academic exchange activities organized by the school, including journal visits and research meetings, and support the reception of international academic guests.
Selected recognition
2025National Scholarship for Graduate Students
2025First-Class Academic Scholarship
2024National First Prize, China Post-Graduate Contest in Mathematical Modelling
2024Outstanding Bachelor Graduate
2024Scholarship for Guaranteed Graduate Admission
05 · Personal
An active participant and organizer in student volunteer activities, with an interest in contributing reliably to the communities around me.
Participated in a German exchange program during high school. The experience gave me early practice in adapting to unfamiliar environments and communicating across cultural contexts.
